03-P104 Transient innervation of retinal axons to the deeper laminae prior to establishment of the lamina-specific projection in chick optic tectum
نویسندگان
چکیده
the embryo, consistent with a shared origin of these cell-types. We also present evidence that iridophore precursors are likely to also have glial potential. Finally, we engineered constitutively active form of ltk gene by analogy with oncogenic gene nucleophosmin-anaplastic lymphoma kinase, and examine the results from experiments asking what happens to NCCs with constitutively active Ltk signaling.
منابع مشابه
Lamina-specific expression of adhesion molecules in developing chick optic tectum.
The optic tectum is the major synaptic target of retinal axons in birds. In the chick, retinal ganglion cell axons enter the optic tectum through a superficial lamina (the stratum opticum), extended branches into deeper laminae, and arborize in specific "retinorecipient" laminae, where they form synapses. Studies using an organotypic culture system have provided evidence that the tectum bears a...
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could not be detected in previous studies, passed through lamina g and invaded deeper laminae such as i/j in SGFS. These invading fibers appear to degenerate as the development proceeds, suggesting that these are pruned at later stages. Based on these results, we suppose a following mechanism. The retinal axons initially invade not only upper laminae but also deeper ones of the optic tectum to ...
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could not be detected in previous studies, passed through lamina g and invaded deeper laminae such as i/j in SGFS. These invading fibers appear to degenerate as the development proceeds, suggesting that these are pruned at later stages. Based on these results, we suppose a following mechanism. The retinal axons initially invade not only upper laminae but also deeper ones of the optic tectum to ...
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Lamination is a central feature of structural organization and segregation within the central nervous system. Afferent fibers typically restrict their synapses to only one or a few specific laminae in the target region. Astroglial cells act as boundary markers for functional segregation of inputs in somatosensory cortex and the olfactory bulb and might also help to segregate particular connecti...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009